Job satisfaction in performing the task is important for the performance and productivity of a person. This study aims to analyze the influence of school’s principal leadership and school culture on teacher’s job satisfaction at the State Islamic Senior High School in Jambi Province. This research uses quantitative research method with path analysis technique, that is R Square analysis, partial hypothesis test with t test and simultaneously with F test, with alpha 5% (0,05). The total population are 890 teachers and 260 teachers as sample with using them as sample of area. Data analysis was done by using SPSS version 20.0 software. The result of this research has shown that the school’s principal and school culture had a significant effect on teacher's job satisfaction either partially or simultaneously.