This review was indicated on healthcare development of Cambodia and Kazakhstan. This paper aimed to comparison studies on healthcare system between Cambodia and Kazakhstan. The healthcare system of these two countries is significantly different, and healthcare reform in Kazakhstan was just a little better than in Cambodia; although, the health situation in both countries was virtually the same, and needs the government to improve more on this sector. The MOH is the principal authority who has overall responsibility on this sector, and strongly assures this sector has been improving. In suggestion, to enhance this sector, MOH should be watchful on policies, legislation, strategic plan, financing and increasing health workforce.