The present study was conducted to find out the occupational stressors towards organizational change with reference to government boys +2 school teachers working in Delhi and New Delhi. It is because of the fact that change is inevitable in the present day world of work; hence, it is often observed that each and every organization is undergoing the process of change. Change in any organization causes stress. Thus, there may be various sources of job/occupational stress that may affect the human working life. Therefore, the present study is of utmost value in the area concerned. The sample area chosen for the present investigation was still an unexplored area. Although, Delhi as a capital of India is making rapid head way especially in academics based on high-info-tech. Total sample consisted of one hundred fifty teachers (N=150), selected randomly from different Government Boys +Schools located in different places of Delhi and New Delhi. Data collected through questionnaires schedules. Having tabulated the data obtained, data were analyzed using standard multiple regression analysis to determine the determinants of organizational change. Results clearly revealed the picture that out of 12 dimensions of occupational stress only two dimensions, viz., „responsibility for persons‟ and „unprofitability‟ have been found predicting organizational change and moreover, two demographic variables, viz., „age‟ and „experience in the present position‟ have also been found as the important determinants of organizational change, although, all the group of teachers working in Government Boys +2 Schools have shown positive inclination towards change. Finally obtained results have been discussed in detail by giving probable reasons in the exigency of situations prevailing in Government Boys +2 Schools from where the present sample has been drawn.