Efficient and increased development of gaseous fuel as a complementary energy source requires a proper understanding of gas flow through pipeline networks and the required solution methods. This paper presents a comparative analysis of flowrate in loop gas pipeline systems using the Hardy Cross iterative method and Pipe 2016 (KYPIPE) computer program. A simple network model with four nodes, five pipe legs and two loops was manually analyzed based on the Hardy Cross procedure using Excel spreadsheet while comparing the effect of friction factors obtained from Moody’s chart, Colebrook’s implicit equation and Jain’s explicit equation on the result obtained from the Hardy Cross method. The accuracy of the result was validated by running a single period flow analysis on Pipe 2016 with the same network. Upon completion, a one-way analysis of variance (ANOVA) test was used to compare the four results while a T-test was used to double-check the three results obtained from the various friction factors based on Hardy Cross individually against the software’s result. Although, the mean plot showed that values obtained from Moody’s Chart and Colebrook’s equation compared more accurately with the software, the AVONA and T-test set at 5% significant level shows that no statistically significant difference exist between the results; making all friction factors suitable for use in gas pipeline flow analysis.