The main objective of this work was to evaluate the physico-chemical and microbiological qualities of dexamethasone sodium phosphate injection in the city of Douala. The experimental type was conducted from December 2016 to June 2017. It consisted of carrying out tests of physic-chemical and microbiological parameters on 14 batches of injectable DSP, conditioning, pH, TLC identification, dosage of active ingredient, the clarity, nominal volume and sterility of the drug were analyzed. The technics used were a visual inspection, thin layer chromatography, UV/visible spectrophotometry and microbiological technics, were that of direct seeding. The results were compared in each sector (formal and informal) and in both. Thus, it was found that the injectable DSP, which came from the formal sector had a non-compliance rate of 12.7%, while that from the informal sector a non-compliance rate of 39.7%. In both sectors, the injectable DSP had a non-compliance rate of around 26.2%. Both formal and informal circuits were all affected by non-compliance, although there is a predominance in the informal circuit.