PT Nexus Fashion & Sports is a manufacturing industry that produces work gloves and sports. The company's current production system has not been able to run effectively and in balance because production demand and production planning always change. Applying the right production system can provide the right production process. The Toyota Production System (TPS) can help companies cope with demand fluctuations and control production planning in a controlled manner. The basis for the implementation of TPS is the principle of heijunka, namely the fundamental removal of mura, muri, and muda. This study aims to measure the effectiveness of the production process and design the TPS based on the principle of heijunka to improve the productivity of human labor. Analysis of production process effectiveness using manufacturing cycle effectiveness (MCE) method was 67% and improvement proposal was 69%. Production rate balancing (mura) on production scheduling of TPS design based on heijunka principle using mixed model scheduling method produces daily flat based production. Alignment of workload (muri) using work load analysis method in March and April 2017 TPS design based on the principle of heijunka there were advantages of 1 person and 4 people. The average human work productivity of TPS design based on heijunka principle increased by 1.10%.