The study aimed to analyze the direct influences of innovation strategies on company performance in Central Sulawesi. This study was conducted in the medium-scale manufacturing industry in Central Sulawesi Province (Palu City and Donggala Regency). The study involved about 96 respondents. The main variables were innovation strategies and company performances. The study found that the average value of the dimension of "process innovation" was 4.11, high category; while the dimension of "product innovation" had an average value of 4.06, high category. The dimension of product performance had a high value of 3.97 and a marketing performance with a value of 3.92. Hypothesis testing showed that there was a significant influence of innovation strategy on company performance with a P-value = 0.00 (P <0.05) and a regression coefficient value of 0.286. The conclusion is that the innovation strategy has a positive and significant effect on the performance of the manufacturing industry in Central Sulawesi.