The coronavirus disease 19 (COVID-19) pandemic is unique and unprecedented in several aspects and has challenged health care systems. It is a worldwide epidemic that creates panic all over the world. So this is a very critical time. This the time to mainstreaming the AYUSH systems to transform Indian healthcare and demonstrate the potential of AYUSH systems in addressing the challenge and restoring health. In India, the world's oldest existing health care system originated. Therefore, it is carefully watched by the world community for how it handles the crisis using its resources. Ayurveda has enough potential and possibilities to be employed both for the prevention and treatment of COVID-19. Charaka Samhita, an essential classical textbook of Ayurveda, describes Janpadiwansa (epidemic) management and defines immunity as the ability to prevent disease. Through Yoga, Meditation, Aasana, Pranayama, we can strengthen our immune system, including our Pranavaha Srotas, our respiratory system. The clapping sound is a kind of Marma therapy & Music therapy. Various Rasayana medicines are used for rejuvenation & improving immunity in Ayurveda. Rising tolls of COVID-19 positive cases and deaths possibly raise anxiety and stress, while depressive and loneliness feelings are likely due to mandatory social distancing measures. Ayurvedic herbs i.e., Ashwagandha, Guduchi, Yasthimadhu, Pippali proved to be beneficial to help fight against the virus. Several steps for mental health are described, which have a potential role in engaging the community in creating a more positive, healthy environment.