Aasavikarana is an age-old technique used in Ayurvedic Pharmaceutics. It dates back to “Rig Veda” which indicates the use of Soma and Sura which has been used in different medicinal preparations, surgical procedures and in many chemical and alchemical operations. Asava Arishtas (medical tincture), and Shukta (acidic fermented product) without doubt is one of the most potent medicinal formulations. Among many other reasons, one cause for its extraordinary performance may be the method of phytochemical extraction from it. The technique of microbial maceration of phytochemical extraction is inviting much attention in nutraceuticals due to its high yield, convenient, energy-saving and cost effective. Aasavikarana is a complex pharmaceutical process of microbial maceration and various other chemical processes like fermentation, Maillard reaction, hydrolysis of polymers and formation of antioxidant species. An effort is made to enlighten the process of microbial maceration in Aasavikarana and their effect on formulations in the present article.