In Ayurveda, Amla-pitta and Shula are the diseases caused by improper digestion of food. Though medical science considered the excessive use of NSAID and Helicobacter Pylori are two leading causes. Infection of H. pylori progresses from gastritis to more severe upper gastrointestinal tract disorders. H. pylori colonize the stomachs of more than half of the human population. In the Vrayatrya (Triad of Major Ayurvedic texts) Amla-pitta is not mentioned. However, Acharya Sushruta, Harita, Kashyap has described Shula in their treatise. For this disorder, single and compound herbal drugs were prescribed. Moreover, Acharya Chakradutta started the use of Iron and calcium-containing compound in compound formulations for the first time. Calcium carbonate is a rapidly acting acid neutralizer. However, the role of iron in these disorders is not clear in terms of modern pharmacology. Iron is an excellent carrier of oxygen, so it ceases the suitable conditions for the survival of micro-aerophilic organisms like H. Pylori. Acharya charka termed this principle of treatment as Prakarti vighata in context of Krimi Chikitsa. So Lauha Bhasma and their compound formulation might be efficiently inhibiting Multi-Drug Resistant Helicobacter pylori.