The thyroid gland is a major endocrine gland. Subclinical hypothyroidism and hyperthyroidism are common health issue particularly in the developing and if remain untreated can manifest serious health consequences. The aim of this study was to figure out the current situation of subclinical thyroid disease in the Pakistani and Afghan refugees living in Quetta city. For this purpose different public sector hospitals were visited on regular bases from October 2018 to October 2019 to find out the prevalence of this disease. Subclinical hypo and hyperthyroid patients of both the nationalities age among 20-70 years were enrolled. Furthermore, the prevalence of clinical sign and symptoms related to thyroidal dysfunction, the physical activities of the patients, use of iodized/non-iodized salt, feeding habit was also recorded. To confirm the status of hypothyroidism and hyperthyroidism the thyroid functional test (TFT) was performed by using Radio Immuno Assay (RIA). Our data showed that the prevalence of Thyroidism was higher in females than males both in Pakistani and Afghani patients. The overall prevalence of euthyroid was (21.66%), hypothyroidism (45.83%) and hyperthyroid (32.52%), thus the prevalence of hypothyroidism was found to be higher than hyperthyroidism and this prevalence was high in the patients among 20-45 years of age. Furthermore, the prevalence data related to clinical sign showed that weight gain (82.12%), cold intolerance (79.60%) and anxiety (74.34%) was more common in hypothyroid patients whereas, weight loss (84.23%), goiter (79.13%) and increase heart rate (78.51%) were the common issues in hyperthyroid patients.