Vitex madiensis Oliv is a plant of the family of the Lamaceae-Viticoideae used in traditional medecine in Congo against: dysenteriform diarrheas, barreness of the women, madness, otitis, tooth decay, oral affections, malaria, inflammation of ganglia and stiffness. The aqueous extract of leaves of Vitex madiensis oliv. was the subject of an investigating by the carraghenine and the histamine induced inflammation, and on the central pain of thermal origin at the doses of 50, 100, 200 and 400 mg/kg per os. A significant anti-inflammatory effect (***p< 0,001) at the dose of 400 mg/kg from the thirst hour and at the dose of 200 mg/kg from 3hours was observed. A significant (***p< 0,001) analgesic effect was observed at the dose of 400 mg/kg from 30 minutes. These effects are due to the presence of the numerous metabolites contained in this extract.