Objectives: To assess the level of oral Mucositis among patient undergoing radiation therapy, to assess the effectiveness of turmeric mouthwash and sodium bicarbonate mouthwash among oral Mucositis patients, to compare the effectiveness of turmeric mouthwash and sodium bicarbonate mouthwash among oral Mucositis patients and to associate the effectiveness of turmeric mouthwash and sodium bicarbonate mouthwash among oral Mucositis patients undergoing radiation therapy with selected demographic and clinical variables. Methodology: Quantitative approach-True experimental comparative design was adopted. Sample size was 60 (30 samples in group I and 30 samples in group II), assigned by simple random sampling technique method was used. National Cancer Institute-Common Toxicity Criteria-Oral Mucositis grading scale was used to measure the pre test of oral Mucositis. The interventions was administration of turmeric mouth wash to group I and sodium bicarbonate mouthwash to group II for 1 minutes for 2 times a day (11 am,7pm) for 1 week for each groups. Post test was conducted for both groups on second week by using the same tool. Findings: By using unpaired t-test the calculated ‘t’ value for experimental group I is t=6.38 which is found significant at < 0.005 level and the ‘t’ value for the experimental group II is t =0.88. Conclusion: The finding proved that turmeric mouthwash is more effective than sodium bicarbonate mouthwash to reduce the level of oral Mucositis.