Callicarpa arborea is a shrub or tree (Family: Verbenaceae) that has been well studied for its antioxidant and antiinflammatory effects. Nevertheless, scientific information on Callicarpa arborea regarding the neuropharmacological effect is limited. The present study was performed to investigate the phytochemical nature and neuropharmacological activities of methanol extract of the Callicarpa arborea (MECA). Phytochemical analysis of Callicarpa arborea extract indicated the presence of flavonoids, tannins, steroid, terpenoid, alkaloids and saponins. The neuropharmacological activity was determined by hole cross and open field test using Swiss albino mice as experimental animal at the doses of 200 and 400 mg/kg body weight. The extract showed significant neuropharmacological activity compared to standard drug. Diazepam at the dose of 1 mg/kg body weight was used as a reference drug in all the experiments. We found that MECA produced a significant dose-dependent inhibition of locomotor activity of mice in both hole cross and open field tests (P<0.05). Our exploration suggests that Callicarpa arborea contains sedative bioactive principle(s).