Medicinal plants have been used in virtually all cultures as a source of medicine. Asthishanharak (pacification of bones) [Cissus quadrangularis Linn.] belonging to Family Vitaceae is also popularly known as hadjod (bone setter) in Hindi. It is a perennial climber widely used in Ayurveda, for Pachana (digestive aid), Sara (relieves constipation), Athiyuk (strengthening bones), Vrishya (Aphrodisiac), Krumighna (destroys worms), Arshoghna (cures piles), Balya (provides strength), Amaghna (Relieves ama – a product of indigestion and altered metabolism), Kushthaghna (cures skin disorders) activities. It possesses calcium oxalate, β-carotene, ascorbic acid, β-sitosterol and 3-ketosteroids, also flavonoids like quercetin, and kaempferol. The stem has two unsymmetrical tetracyclic triterpenoids, onocer-7-ene-3α, 21β-diol and onocer- 7-ene-3β, 21 α –diol, two steroidal principles I and II, δ-amyrin, δ-amyrone. It has been reported to have bone fracture healing, Antioxidant, Free radical scavenging, Anti-microbial, Anti-fungal, Anti-bacterial activity, Anti-fungal, Anti- viral activity, Anti-ulcer activity, Analgesic, anti-inflammatory and stimulatory activity, Anti-obesity activity, Anti-pyretic activity, Anti-haemorrhoidal activity, Anti-tumour and cytotoxic activity, Anti-helminthic activity and Gastro-protective activities etc. Considering its therapeutic values, a review has been done to compile information on Ayurvedic aspect of Asthisanharak. Moreover Ayurvedic references, the present paper also emphasizes on its pharmacognostical studies, phytochemical constituents and researches conducted on this plant for its clinical and pharmacological evaluation which would be worthwhile to explore its unique features.