Medicated soaps for external uses are necessary to avoid related infections or diseases caused by some microorganisms. In the present study, four medicated soaps: Dettol, Protex, Dermoviva, and AB+ were investigated for their antimicrobial activities against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Salmonella sp and Candida albicans. Marseille soap was used as control. The antimicrobial effectiveness of selected medicated soaps was determined using paper disc and well methods. Soaps tested in the present research work showed varied levels of activity against the tested microbes. Among them, AB+ was the most active product, while Protex showed the lowest activity against the tested organisms’ species.