During pregnancy there is a physiological hypercoagulability which may be increased by genetic risk factors and / or acquired thrombosis. This increases the risk of thromboembolism and the risk of thrombosis in placental vessels and thus termination of pregnancy. Among genetic risk factors for thrombosis, factor V Leiden and mutated factor II are responsible for spontaneous miscarriages, which are essentially late. The rare deficits in antithrombin, protein C and protein S are also involved. Factor V Leiden is a thrombophilic condition that can lead to serious thromboembolic events and in pregnant women recurrent miscarriages. We report the case of a 36-year-old woman who presented 6 miscarriages that led to the diagnosis of thrombophilia by resistance to activated protein C and whose last 4 pregnancies were well followed by anticoagulant treatment with low molecular weight heparin aspirin.