Pre-eclampsia is characterized by high blood pressure (hypertension), fluid retention (oedema) and excessive protein levels in the urine (proteinuria). These symptoms are not evident during the early stages of pregnancy and as such preeclampsia can be difficult to diagnose. It is only detectable by regular antenatal checks on maternal blood pressure and urine, and as such women without access to adequate healthcare services are particularly at risk. This study intended to assess the knowledge regarding Pre-Eclampsia Toxemia among antenatal mothers. A descriptive study was conducted in primary health centre outpatient department at Karanchavadi with 50 samples who were recruited by non-probability convenient sampling technique. Data gathering was carried out with a semi structured questionnaires and the major findings of the study reveals that 8 (16%) had adequate knowledge, 15 (30%) had moderate knowledge and 27 (54%) had inadequate knowledge on Pre-Eclampsia Toxemia among antenatal mother. There are significant associations between levels of knowledge with demographic variables such as age and occupation. The study suggests creating the awareness among the antenatal mothers by an awareness among antenatal mother help in improve their health.