Introduction: Sickle cell disease (SCD) results from the substitution of a valine residue for glutamic acid at position 6 in the beta-subunit of hemoglobin. It is characterized by chronic hemolytic anemia, vaso-occlusive process and multiple organ infarction resulting from wide spread vascular occlusion. Sickle cell disease is the most common inherited disorder worldwide. Pregnancy in sickle cell disease is at very high risk. Many reports have documented a considerable maternal risk of morbidity and mortality and high peri-natal adverse outcomes. Case report: 26 year old G3P1D1A1 presented with 39 weeks 4 days gestation with gestational hypertension with mild tricuspid regurgitation with pulmonary hypertension. She was diagnosed with sickle cell disease. Results: Patient is taken for emergency LSCS and transfused with 1 pint packed cells along with Thrombo prophylaxis. Both mother and baby are doing well till date. Conclusion: This case report highlights the fact that anemia in pregnancy should be evaluated systematically and early diagnosis and effective multidisciplinary approach will yield a better maternal and neonatal outcome.