The extraction technology of total flavonoid from dandelion was optimized by single factor screening and orthogonal test. The method of solvent extraction was used, and ethyl acetate was used as solvent, solid-liquid ratio, extraction temperature and extraction time were invested to study the effects of the extraction. On the basis of single factor, three-factor and three-level orthogonal test were carried out to optimize the extraction process of flavonoid from dandelion. The results showed that the factors of the extraction effect of flavonoid were influenced by the time of extraction, the ratio of material to liquid, and the temperature of extraction in turn, it was found that the time of extraction had the most significant effect on the extraction of flavonoid from dandelion. The results showed that the optimal conditions of extraction were as following: the ratio of solid-liquid was 1:70, the temperature of extraction was at 70 ℃, and the time of extraction was 1.5 h. Flavonoid was extracted from dandelion at the best conditions, flavonoid was obtained, and the content of flavonoid was 7.18%. The process is simple, reproducible, economical and feasible.