Small-scale farmers’ vulnerability to agropesticides depends largely on their attitudes and practices vis-à-vis these pesticides. This paper hinges on the causes of small-scale farmers’ vulnerability to pesticide use on market garden crops in M’muockngie, South West Region of Cameroon. This study made use of household surveys to identify the origin of pesticide, types, frequency of use and the causes of farmers’ vulnerability to pesticides health effects. Data analysis was at the same time manual and numeric. Findings revealed that, over 56% of small-scale farmers buy chemicals from local agrochemical input dealers. The poor handling of pesticide by small-scale farmers causes diseases like cough, itch, catarrh, nausea/vomiting, and eye redness as over 60% of farmers store pesticides at home which increases the risk of contamination. Chi-Square test results revealed that there was a significant difference between small-scale farmers’ level of education as a cause of their vulnerability to pesticides harmful effects and some hypothesized explanatory variables (p<0.05). Training in pesticides use and the adoption of environmental-smart methods remain the best solution to safe farmers from this danger.