The aim of this research paper is to know the challenges faced by formal and informal sectors in disposing e-waste in Nairobi County. It also tried to identify the e-waste management strategies applied by formal and informal sectors in the county. A total of 400 personals were selected; 250 from informal sector, 150 from formal sectors. Simple random method was used to select the participants included in the sample and stratified sampling method was used to select the sectors involved in e-waste management from which the sample was selected. Questionnaires, environmental observation checklist and Interview guide were designed to ask members of the two sectors, the management strategies they apply and the challenges they face in managing e-waste. It was found that most of the e-waste was not disposed; instead it was stored in warehouses and the percentage disposed it was mainly poorly disposed. Factors which contributed to poor disposal and accumulation of e-waste in warehouses included: Lack of procedures of disposing specific e-waste and lack of information on where to take the WEEE. Different challenges affecting e-waste management strategies were also realized and included: Financial constraints, Disease, Lack of handling procedures, limited number of official dumpsites, access and infrastructure and lack of environmental awareness.