Introduction: As a new media, WeChat has both negative and positive effects on college students. This paper first analyzes the developmen status of WeChat in the population and the characteristics of college students' social interaction. Then we conducted a survey on the use of WeChat by college students of Anyang Normal University, focusing on the reasons, duration, WeChat main newsletter, communication of WeChat, and the discrimination between the true and false of WeChat information. We discuss the positive and negative impact of WeChat on college students. Finally, in view of the negative influence of WeChat, we give the corresponding strategic measures from three levels: college students themselves, universities, and university educators, so that college students can overcome and avoid the negative effects of WeChat, so as to better grow into talents.