The purpose of the study was to establish the relationship between students’ perception and performance .The theories that guided the study were theory of leaning and Constructivism theory. In this study the design used was correlation survey design. The target population that involved in this study is 16 public schools in Moshi municipality. Samplings used in this study were stratified and simple randomly sampling. The instruments that used to obtain the data in this study were questionnaire for students and interview schedule for teachers. The main findings were Perceptions of students towards science subjects in Moshi municipality Relationship between student’s perception and academic performance towards science subjects in Moshi municipality, Improvement perceptions of students towards science subjects and challenges facing students’ performance on science subjects in Moshi municipality. The study concluded that there is strong relationship between students’ perceptions and performance towards science subjects. The researcher made recommends that the ministry of education and vocational training must establish union among students who studying science subjects and prepare gifts and incentives for all students who performing better in science subjects, this situation will increase interest of students to study science.