Background: Thyroid dysfunction is relatively a common disease which affects people, irrespective of their age and gender. Hypothyroidism is a clinical syndrome resulting from deficiency of thyroid hormones, which in turn results in a generalized slowing down of the metabolic processes. Newly diagnosed hypothyroidism has been reported to be associated with inflammation, dyslipidemia which leads to CV risk. hs-CRP is a marker of subclinical inflammation and a predictor of CVD. Vitamin D deficiency is involved in autoimmune diseases, metabolic syndromes, cardiovascular disease, and cancers. Recent evidence has demonstrated an association between low vitamin D status and autoimmune thyroid diseases. Objectives: The aim of the present study was to compare vitamin D, hs CRP levels and lipid profile with that of thyroid profile among newly diagnosed hypothyroid subjects. Materials and methods: A total of 70 subjects with the clinical features and investigative reports suggestive of hypothyroidism and newly diagnosed as hypothyroid patients in General Medicine department, Meenakshi medical college, kanchipuram, were compared with 70 healthy controls. Results: The levels of vitamin D were significantly reduced compared to controls and negatively correlate with TSH in hypothyroid cases. hs-CRP levels were significantly increased and positively correlate with TSH in hypothyroid patients. Total cholesterol and TGL levels were significantly higher compared to control group and positively correlate with TSH in hypothyroid cases but the level of HDL was significantly reduced compared to controls and negatively correlate with TSH in hypothyroid patients. Conclusion: Our results indicated that newly diagnosed hypothyroid patients become an important entity due to possible link between diagnosed hypothyroid patients and cardiovascular risk factors, especially lipid abnormalities and alteration of BMI levels. Patients with hypothyroidism suffered from hypovitaminosis D and also significant association between TSH and hs-CRP is an important finding in this study.