Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder because of absolute or relative deficiency of insulin production by the beta cells of the pancreas. Trace elements like Zinc and copper are known to affect the synthesis, secretion, release and mechanism of action of insulin. Dyslipidemia is an associated abnormality in most of T2DM patients and the underlying mechanism is not resolved well. Estimation of the trace elements and lipid profile in newly diagnosed T2DM patients will help to identify the onset of early oxidative damage and prevent various complications of T2DM. The present case control study incorporated age and sex matched 48 type 2 diabetic patients and 48 apparently healthy adults. Copper was estimated by Di-Br-PAESA method and Zinc by Nitro PAPS method on Chem 7. HDL-C and TGL quantification was done by EM200 Fully auto analyzer by respective kits from manufacturer. The present study showed that trace elements like serum Copper levels were significantly increased (P < 0.001) where as serum Zinc levels were significantly decreased (P < 0.001).At the same time HDL-C was significantly decreased (P < 0.001) and TGL significantly increased (P < 0.001) in diabetic patients in comparison to controls. Abnormalities in trace elements metabolism and deranged lipid profile may add to the increased risk of complications in T2DM. Early estimation of trace elements and supplementation of the same with therapeutic intervention and correction of lipid abnormalities will help to improve the treatment outcome in these patients.