Introduction: Hypothyroidism is receiving greater attention as an important cause of disturbance in mineral metabolism by its direct action on bone turnover, and also as one of the causes for secondary osteoporosis. Calcium (Ca2+), phosphorus (PO4 2−), and magnesium (Mg2+) are necessary for metalloenzymes and various crucial metabolic pathways directly or indirectly regulated by thyroid hormones. Methodology: Patients attending the General Medicine department who were diagnosed clinically as hypothyroid for the first time (n=120) and referred to the central laboratory for thyroid function tests were enrolled for the study. 60 normal healthy individuals were chosen as controls. Results: In hypothyroid patients, the mean values of calcium and magnesium were found to be higher compared to that of the controls’. Whereas mean value of phosphorous was found to be lower compared to that of the controls’. Conclusion: Serum calcium, magnesium & phosphorous levels are widely altered in patients having hypothyroidism. So we suggest that constant monitoring of these minerals in hypothyroid patients will be of great benefit in improving clinical manifestation. Complications can be avoided by planning holistic disease management strategies for these patients.