Helicobacter pylori (H. pylori) is a gram negative bacterium that naturally colonizes the gastric epithelium, which causes chronic gastritis and peptic ulcer disease. Recent studies have shown that it may interfere with many biological processes and influence the occurrence of many diseases outside the stomach. Many studies have proposed a link between H. pylori infection and atherosclerosis. Atherogenic Index of Plasma (AIP) has been considered as a strong marker to predict the risk of atherosclerosis. The present study was done to assess the correlation between AIP and other lipid indices with H. pylori infection. The study comprised of 50 biopsy proven H. pylori cases and 50 age-sex matched controls. Blood samples were collected in fasting state and analyzed for total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HDL) and LDL-cholesterol and the lipid indices were calculated. Lipid indices like AIP, CRI 1 & 2 & AC were significantly higher in H. pylori infected cases compared to controls. Hence these lipid indices can be used for identifying individuals at higher risk of cardiovascular diseases in H. pylori infected patients.