Hypothyroidism is a common endocrine disorder associated with increase in peripheral vascular resistance and decreased cardiac output. The increase in peripheral resistance can predispose to alteration in renal hemodynamics including reduced renal blood flow associated with diminution of glomerular filtration. The study was taken up to determine the influence of thyroid hormones on serum cystatin C, creatine kinase and creatinine level in hypothyroids and to determine the extent of renal involvement in these cases. Serum T3, T4, TSH, Total creatine kinase, Cystatin C and creatinine levels were estimated. Creatinine clearance was calculated using Cockcroft Gault formula and eGFR by using MDRD formula. The elevation of serum creatinine levels in hypothyroids in the study may be due to increase in total creatine kinase level either due to myopathy or due to decreased clearance by kidney. In the study there is paradoxical relation of elevation of serum creatinine and decrease in serum cystatin C in hypothyroidism.