Chlorpyrifos is among the commonly used pesticides used for self-harm. Chlorpyrifos is colorless crystal like solid with a strong odor. Pesticides like chlorpyrifos are necessarily poisonous but they play an important role in the availability of plenty of cheap and consistent supplies of food to the world population. The aims of this review article investigated the aspects to reduce the risk due to chlorpyrifos use among farmers and people by producing awareness. A decreased percentage of neutrophils in peripheral blood in animals poisoned with chlorpyrifos may suggest, neutrophils involves in phagocytosis during xenobiotic intoxication, during which some of the neutrophils might have ruptured. Chlorpyrifos modifies testicular capacities perhaps by acceptance of testicular oxidative pressure and hindrance of exercises of indicator catalysts, accordingly disturbing masculine generation. The outcome enemies of oxidants i.e SOD, CAT, G6PDH exercises in the hepatocytes, renal, spleen and cerebrum of rodents. The sub- deadly presentation of chlorpyrifos additionally cause decline in dimension of decreased GTH (glutathione) and ensuing increment in oxidized glutathione heights. So the outcome demonstrate that CPF presentation prompt oxidative worry in rodent tissues however the CPF introduction to rodents feed with oxidants vitamin A,E and C for one month, averted unhinging of these enemy of oxidant limits. It also helpful to explain the mechanism that chlorpyrifos induce such changes in living organisms included humans.