In this work, the facies of blood serum were studied in patients with liver pathologies and pathological markers were identified, and information on their crystallographic features was given. To solve the set tasks, wedge dehydration methods, computer morphometry, biochemical, microscopic and statistical research methods were used. The work studied the correlation between the features of the change from the norm, the magnitude of informative biochemical blood parameters of patients with established diagnoses of liver pathology, as well as the qualitative and quantitative characteristics of the morphotexture of the solid phase facies of their blood.