Elicitors are the synthetic or naturally occurring molecules, which capable of trigger the plant defense mechanism against the plant pathogens and environmental hazards. Plants deploy a number of defense mechanism against the phytopathogens and elicitors can able to induce the production of secondary metabolites to facilitate the biochemical defense mechanism, which eventually leads to plant resistance. Biotic elicitors are the type of elicitors that have the biological origin and derived from the pathogen or from the plant itself. To induce the plant resistant, initially biotic elicitors need to go through with microbial-associated molecular patterns (MAMPs, also called PAMPs). As well, the plants have evolved other receptors to detect the elicitors and leads to gene mediate resistance mechanism against the pathogens. This review discusses such biotic elicitors and their way to induce the disease resistance.