The parasitic weed Striga hermonthica poses a serious threat to sorghum production in Northern Cameroon. To evaluate the response to S. hermonthica of 24 genotypes of rainfed sorghum and the effect of sodium carbonate on this parasite, field and pot experiments were conducted at Touboro (North Cameroon) in 2016 and 2017. In pot and in field, under striga infestation, results showed varietal responses of sorghum for the number of emerged Striga, the height of sorghum, the stem diameter, the number of leaves per plant, the panicle weight and the grain yield. Globally, Striga infestation significantly reduced the height, the stem diameter, and the number of leaves, the panicle weight and the grain yield of sorghum accessions by 28.94%, 19.54%, 17.78%, 28.24% and 44.17% respectively. Application of natural sodium carbonate salt reduced significantly the emerged Striga and the host plant damage by 74.29% and 41.94%. Under Striga infestation, sodium carbonate also increased the growth and yield sorghum accessions. Among the 24 studied genotypes, complete resistance was no recorded, but landraces LMO-LT18, LMO-LT22, KW-CP09 and LMT-21 appeared as the most resistant and tolerant to S. hermonthica. Combination of sodium carbonate with resistant and tolerant genotypes should be investigated as a major component of integrated packages to the effective control of Striga on sorghum in northern Cameroon.