A total of seventy five (75) marine fishes comprising eight (8) species were collected from local wholesale markets at Kaneshie and Abeka, Accra, Ghana. The samples obtained from Kaneshie market were Salmon salar (Salmon), Thunnus obesus (Tuna), Scomber scombrus(Atlantic mackerel) and Clupea harengus (Atlantic herring) and those obtained from Abeka market were Centroberyx affinis (Red fish), Merluccus paradoxas(Hake fish), Scomber trachurus (Atlantic horse mackerel) and Melanogrammus aeglefinus(Haddock). Mercury concentrations in the muscle and liver tissues were determined by cold vapour atomic absorption spectrophotometry using a semi-automated mercury analyzer. Mean mercury concentrations in the muscle ranged from 0.06 to 0.33 µg g-1 wet weight, with Thunnus obesus having the highest followed by Merluccus paradoxas which are all predatory fishes. Mean mercury concentration in the liver tissue ranged from 0.06 to 0.34 µg g-1 wet weight, with Thunnus obesus having the highest followed by Melanogrammus aeglefinus. There was no significant difference between mercury concentrations in the muscle and liver tissues for any of the samples. Low levels of mercury were found in both tissues for all the samples. Mercury concentrations were relatively greater in the tissues of higher trophic level fish such as Thunnus obesus, Merluccus paradoxas and Melanogrammus aeglefinus whereas low trophic level fishes recorded low mercury concentrations. The results obtained for total mercury concentration in the muscles analyzed in this study were below the WHO/FAO threshold limit of 0.5µg/g wet weight, which suggest that the exposure of the general public to mercury through fish consumption can be considered negligible.