Myristica fragrans seed (Nutmeg) famed as the prominent fatty seed of medicinal and therapeutic quality came from the Spice island of Indonesia. It is endowed with phytochemicals, minerals and vitamins impart medicinal values. In captive conditions the ornamental fishes with deprived nutritional feed subjected to diseases and faded colour produces economic loss in their trade operations can be tackled by effective administration of plant products. In this perspective, a comparative study made in Poecilia latipinna (yellow molly)by providing (commercial feed) CF and TD1 (Myristica fragrans) for a duration of 60 days. The in vivo antibacterial efficacy of feed in tissues(gut & gill) of the specimen along with water samples from aquaria revealed positive result for TD1.The colour enhancing ability in yellow molly yielded best result higher for TD1 considered to CF. The total bacterial load in the water, gut as well as the gill of CF fed group was 75x104 CFU/ml, 45x104 CFU/ml& 23x104 CFU/ml while for TD1 it was 14x104 CFU/ml, 9x104 CFU/ml, 7x104CFU/ml. The quantitative estimation of carotenoids estimated was 6.32µµg/g wet weight in control and 12.12µg/g wet weight for TD1.From the present investigation arrived at the conclusion that TD1 provided better anti-bacterial activity than CF (commercial feed) not only prevent disease outbreak but also produce vibrant skin colour.