Vascular tissues respond as an inflammation to adverse stimuli like pathogens, bruised cells or an irritant. An inflammation manifests itself as redness, swollen joints, pain at joints, stiff joints and impaired joints. Currently inflammation is treated by NSAIDS. However, drugs used to treat inflammation can potentially lead to enhanced risks of blood clotting which in turn can end up fatal heart attacks or strokes. This scenario has hence necessitated a search for alternate drugs derived from medicinal plants. Their chemical diversity also make them rich and possible sources of drugs without accompanying adverse side effect. Therefore a study in this direction will be both rewarding and unfulfilling. The objective of this study was to evaluate the antiinflammatory activity from the ethanol extract of whole plant of Caralluma umbellata in carrageenan induced paw edema in Wistar Albino rats. This study was compared to a positive control drug, indomethacin. The ethanol extract was given in a concentration of 200 and 400 mg/kg body weight. Ethanol extract of C. umbellata whole plant with a concentration of 400 mg/kg b.w. showed maximum (85.44%) inhibition on carrageenan induced rat paw edema at 3rd hour. The effect was significantly (p<0.001) higher than that of the standard drug indomethacin (84. 78%). From the result, it can be concluded that the antiinflammatory activity of C.umbellata ethanol extract of whole plant may be due to the presence of secondary metabolites in the extract.