Rheumatoid Arthritis is an autoimmune disease which consists Joint pain, inflammation, synovial proliferation and damage of articular cartilage. Morning stiffness along with joints pain is a primary diagnosis. If not treated it can lead deformity of the wrist, fingers, toes. NSAIDs are the first line treatment. Now a days DMARDs are frequently used as soon as RA is confirmed along with some corticosteroids. The present study reveals that use of prednisolone has a miraculous pain relieving effect over deflazacort even for short term regime.