Filariasis (Philariasis) is a parasitic and infectious tropical disease that is caused by thread-like filarial nematode worms and their larvae. Filariasis is rarely fatal and it is the second leading cause of permanent and long-term disability in the world. The larvae transmit the disease to humans through a mosquito bite. Considering the Tubulin protein as drug target, which is the principle component of the Microtubular system in the filarial nematodes, the drugs were found by using the Drug Bank and their analogs by using NCI Enhanced Database Browser. Benzimidazole carbamates, a class of microtubule depolymerizing drugs was found to act by disrupting the assembly of tubulin dimers into microtubules. Thus the filarial nematode muscular system gets severely affected. The Filariasis can be prevented and eradicated by administrating one of the drugs belonging to benzimidazole carbamates class. Using Discovery Studio Visualisation tool, the analogs of this class of drugs were docked with the tubulin protein and novel drug was identified for an effective treatment against Filaria.