Marine macroalgae produce a great variety of biological active compounds which cannot be scientifically characterized with in other organism’s biomass. These marine habitats have been scientifically reported for modern medicinal uses although rheteoratically associated to coastal communities’ healthy eating and folk medicine practice. In tandem to this, these marine macroalgae have highly potentiate themselves as a tangible source of functional ingredients that is industrial applicable. Globally various division of geochemical marine macroalgae flora taxa (Chlorophyta, Phaeophyta, and Rhodophyta) flourish. However, despite substantial optimised yield and empirical evidence of their health potential benefits, these macroalgae remained largely pharmaceutical and medical related industries innovative unexploited. Of these leads compounds, sulfated polysaccharides offer a wide range of physiological and chemical-biological activities that include antioxidative, anticoagulant, antiviral, antitumor, anti-inflammatory, antihyperlipidemic and antihepatotoxic activities. Per se, the optimization of sulfated polysaccharides as functional food and Vis a Vis, as therapeutic agents is this millennium important research agenda. As such, this review extrapolates the bioprospect of sulfated polysaccharides (Sulfated galactans, Fucans, and Ulvans) from geochemical signature macroalgae potential context as functional food and as tangible source for drug discovery.