Nutritional and industrial processes have increased the demand of oils and this in turn has led to the search for oils from different types of seeds for possible development and use. It is in this vein that the Tetracarpidium conophorumfruit nuts were extracted with n-hexane (soxhlet extraction at 650C). The proximate composition,antinutrient and mineral content of freshly harvested Tetracarpidium conophorum(African walnut)seed from 4 weeks after anthesis (WAA) to fruit maturation were assessed in this study. Data obtained for the proximate composition at matured stage of fruits developmentrevealed significant high amount of fat(43.4±0.82) %; moisture(36.7±1.39) %; crude protein(30.1±1.38) %; carbohydrate (16.91±1.07) %;low crude fibre (2.59±0.64) %, and ash content(7.3±0.07) %[which contained higher amount ofminerals such as of Fe (130.81 ± 3.8) ppm, Mn (40.11 ± 1.00) ppm, Ni (2.92 ± 0.81) ppm, and Cu (12.01 ± 0.71) ppm, decrease inCa (1.082 ± 0.08) %, Cr and Cd were not detected throughout the period] at 20 WAA compare to immature stages of 4, 6, 8, 10, 12, 14 and 16 WAA. The level of antinutrientfactors are oxalate (0.46±0.05) mg/100g; Phytate (29.2±0.44) mg/100g and cyanogenic glycosides (0.17±0.07) recorded lower content, except tannins (90.5 ±3.93) mg/100gwhich recorded significant (p < 0.05) higher content at 20 WAA when compared with immaturestages in 4, 6, 8, 10, 12, 14 and 16 WAA. This study revealed the nutritional profile of the fruitnut as good sources of plant protein, carbohydrate and fat, with reduction in the level of some anti-nutrients in matured fruits which are potentials that could be exploited by food and pharmaceutical industries.