The actual situation in Ethiopian farmers is alarming and calls for an intensive work on assessing pesticide use and practice, educating the farmers on good pesticide managements; sensitize the local community about consequences in misuse of pesticides. In this study one of the largest Districts of Borena Zone in the Oromya region of Ethiopia was considered to survey the pesticide use and practice of farmers. Kebele based cross-sectional comparative study was conducted using self administered questionnaires. A total of 413 study units were involved in the survey with response rate of 98 %. About 82 % of the study participants use chemical pesticides at different levels. Among the farmers who take part in spray operation, 92.48 % worn any ordinary suit with old rubber shoes during spraying and formulation. Based on the survey 75.22 % of the respondents claimed illness after pesticide spraying. Communities should adopt nopesticide policies and launch community education programs.