Studies in the Antimicrobial Activities of Some Newly Synthesized [1,4] Substituted Benzodiazepines by Disc Diffusion Method and MIC Methods
D. T. Tayade, P. R. Kale, S. A. Waghmare, A. P. Nagarale
Abstract
Recently in this laboratory 8-phenylthiacabamido-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]
benzodiazepine i.e.M-1, 8-(phenyl-2,4-dithiabiureto)-1-methyl-6-phenyl-4H-[1,2,4] triazolo[4,3-a][1,4] benzodiazepine
i.e.M-2, 8-[(3-phenylimino)-1,2,4-dithiazolo]-amino-1-methyl-6-phenyl-4H-[1,2,4]triazolo [4,3-a][1,4] benzodiazepine
i.e.M-3, 8-[(2-phenylimino-6-phenylamino)-1,3,5-dithiazinoimino]-1-methyl-6-phenyl-4H-[1,2,4] triazolo[4,3-
a][1,4]benzodiazepine i.e.M-4, 8-[(2-thio-3-phenyl-6-phenylamino)-1,3,5-thiadi- azino]imino-1-methyl-6-phenyl-4H-
[1,2,4] triazolo [4,3-a] [1,4] benzodiazepine i.e.M-5 were synthesized and their antimicrobial activities were tested
against E. coli, B. subtilis, S. typhi, S. aureus, B. megatherium, A. aerogenes, P. vulgaris by Disc diffusion method and
MIC methods. These compounds showed good results.
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