The present study involves assessment of water quality of Kshipra river by use of control chart, water quality index (WQI), physico-chemical and microbiological analysis. Samples were collected from five sites of the river for a period of one year. The main purpose of the study is to provide a baseline data regarding pollution control, management and improvement of water quality of this river before Mahakumbh 2016. Analysis of various parameters like dissolved oxygen (DO), chemical oxygen demand (COD), biological oxygen demand (BOD), total coliform (TC), fecal coliform (FC), turbidity, transparency, total alkalinity, total hardness, chloride, calcium was performed.WQI values ranged from 284.0-1112.34 and shows all study site to be under pollution stress. Results of the present investigation showed that water quality of the river is more deteriorated during summer followed by monsoon and winter season. Control chart model is applied for the first time in the analysis of water quality, as it provides a clear pictorial view about the pollution status of the river. The sample mean values in control chart cross lower and upper limits consistently in all seasons and at all study site, indicating very poor water quality. Higher pollution load was observed in Ramghat followed by Managalnath, Triveni, Mahidpur and Kshipra village study sites. According to CPCB water of Kshipra river is found to be of D class and river is observed to be under great pollution stress. Immediate remedial measures are recommended to control pollution and improve water quality of the river which is important for proper management and conservation of this holy river.