Obesity and health problems have been observed that reduces productivity and increases absenteeism. Although the relationship between health and productivity is strong, few studies have examined whether the level of obesity and physical activity affect the absence from work and how the health-related habits are affected. The aim of this study was to examine the relations between job stress body fat, physical fitness levels, health-related habits and absenteeism, among 440 office workers of public sector and private sector companies of Greece employee population. Significant differences observed in the absence days between normal weight (NW) individuals (3.07 ± 1.7), overweight (8.56 ± 3.08) and obese (12.62 ± 10.1). The regression analysis model present an R value of 0.814, p<0.05 and shows that 65.8 % of variance in absenteeism is being explained by body fat percentage, VO2max flexibility level and the job stressors role and demand In addition, NW employees consume significantly less fast food meals (2.26 ± 1.76) a week compared to overweight (3.72 ± 1.91) and obese (3.54 ± 1.61). This study provides evidence that obesity and lack of physical activity affect the absent days from work. Higher body fat is also associated with unhealthy attitudes.