This study aims to determine the effect of government spending on education, health, and minimum wages on the Five Human Development Index in Southern Sumatra Province. The analytical tool used is panel data with the study period of 2007 to 2016 in five southern Sumatra Provinces namely Jambi, South Sumatra, Bengkulu, Lampung and Bangka Belitung. The results show that minimum wages are the most dominant variable and have a significant effect on the HDI. Whereas the other two variables, namely government spending in education and health do not significantly affect the HDI. Overall the HDI average is not much different and there is no discrepancy between provinces in Southern Sumatra from the range of 68 percent to 70 percent. However, of the five provinces in Southern Sumatra, there are two provinces with higher HDI figures than the others, namely Jambi Province and Bangka Belitung Province.