Background: Escherichia coli is one of the commonest pathogens causing community acquired Urinary Tract Infection (UTI). Increase in resistance to antibiotics and limited option of oral antibiotics for UTI calls for search for better alternative options. Extended Spectrum Beta Lactamase producing E. coli (ESBL- EC) further reduces the therapeutic options complicating the management. Nitrofurantoin (NIT) is one of the commonly prescribed oral drugs and Fosfomycin (FO) though an old drug is regaining its medical importance. The aim of the study was to study and compare the sensitivity of NIT and FO in ESBL-EC causing UTI. Material and Method: A total of 215 mid-stream urine samples showing growth of E. coli were collected and ESBL-EC identified. Antibiotic sensitivity testing was done by Kirby Bauer disc diffusion method as per CLSI 2019 guidelines using NIT (300μg) and FO (200μg) discs. The results were compared. Result: Out of 215 urine sample, 57(26.5%) isolates showed resistance to NIT while FO resistance was observed only in 11 (5.1%) of the isolates. Amongst isolated E. coli, 122 (56.7%) were extended spectrum beta lactamase (ESBL). Among the resistant isolates, ESBL producers were 45.5% (5 out of 11) and 57.8% (33 out of 57) for FO and NIT respectively. Conclusion: Increase in resistance trend in NIT calls for search of other oral options for treatment and FO promises to be one of them.