Pre-eclampsia is an important clinical syndrome with an elevated blood pressure and marked proteinuria and may be associated with haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. Recently, oxidative stress is thought to play a role in the pathogenesis of pre-eclampsia. The current research consisted of 77 women with pre-eclampsia and 45 normotensive subjects attending Rasheed Shekoni specialist hospital and General hospital Dutse. Serum antioxidant vitamins A, C, E and some hematological indices were analyzed in both groups. Results revealed a statistical decrease (p<0.005) of vitamin A, C, E and platelet in pre-eclamptic compared to normotensive women. Antioxidant and platelet concentrate supplementation may supress the development of pre-eclampsia.