HCC is the one of the most common of cancers and now according to world statistics it accounts for fifth most common types of cancer in the world. The mortality is very high and it second leading cancer in terms of cancer-related mortality in the world. The frequency has been on a study rise in the last one or two decades. It is one of the serious malignancies and has one of the worst prognoses in terms of morbidity and mortality. The numbers are expected to increase in the next decade or two as more and more urbanisation and industrialisation are happening thus indirectly leading to life style modifications. Liver is the mainly concerned with the metabolism and it is easily targeted as it is the first line of defence or contact as far as the ingestion is concerned. Toxic environment is one of the most important causes. With increase in the incidence and prevalence of the toxic substances being ingested and also the unhealthy life style followings is being practised, more number of cases is expected to encounter. If global scenario is considered then higher incidence is reported in the developed and industrialised nations. This study puts in an effort to profile the Hepato-Cellular Carcinoma cases.