The head and neck cancer are sixth most common cancers worldwide with cancer of oral cavity. The basic treatment modality for the carcinoma of oral cavity has been surgery and the large defects resulting from the ablation of the tumors require reconstruction. The PMMC flap offer an easy, less time consuming with minimal postoperative complication as a reconstructive option in the hands of surgeon. In the present case report, 32 years old male patient was diagnosed with squamous cell carcinoma of right buccal mucosa and treatment plan was right segmental mandibulectomy and reconstruction by PMMC. A major pecto¬ralis myocutaneous flap was used to reconstruct a composite oro¬mandibular defect with excellent cosmetic and functional outcome. It provided a suitable and cost-effective reconstruction with low microsurgical risk, relatively short operative time, sufficient soft-tissue replacement and minimum donor site morbidity. Pectoralis major myocutaneous flap was found to be a versatile flap for reconstruction of large defects in Head and Neck region with minimal complication rate.