Introduction: Schizophrenia is a chronic and debilitating psychiatric condition that constitutes a real public health problem. Antipsychotics have changed the management of schizophrenia, but the cases of resistance are more and more important. Methodology: Retrospective descriptive study carried out at the Razi hospital concerning the files of patients with resistant schizophrenia hospitalized during the period spanning 3 years, from 2013 to 2015. Inclusion criteria: Cases of schizophrenia and resistant schizoaffective disorder are defined according to DSM 5 criteria and Kane's resistance criteria. Exclusion criteria: Insufficient clinical information on the file Patients with neurological disease or intellectual disability. Statistical tool: SPSS 20. Results: The average age is 33 years old. An age range between 19 and 53 years old. All our patients are male. In our sample of 33 patients, 64.3% have problematic drug use (tobacco, cannabis ...). 92.9% of our patients are schizophrenic and 7.1% have schizoaffective disorder. The age of onset of the disease is around 21 years old. Half of our patients had haloperidol as initial therapy. The diagnosis time of the disease resistance is on average 2 years. 78.6% of our patients were treated with clozapine alone, 13.3% with clozapine + antipsychotic and 7.1% with clozapine + thymoregulator. In 41% of the cases there was an improvement under these treatments and no response in 59% of the patients.